Evolution of Kidney Disease in Single Ventricle Patients After Cardiac Transplantation

PurposeUnlike Fontan-associated liver disease, the impact of heart transplant (HT) on Fontan associated kidney disease has not been well described. In this single center study, we sought to characterize natural history chronic in a small cohort patients from listing follow up after HT.MethodsWe conducted retrospective review pediatric at our institution with prior palliation that underwent HT between 2000-2020. We collected demographic information, data regarding baseline renal function/anatomic abnormalities, presence protein losing enteropathy/liver disease/renal insufficiency/diabetes, and cardiac hemodynamics. Estimated glomerular filtration rate (eGFR) was calculated based serum creatinine (Cr) using Cr-based “Bedside Schwartz” formula which used determine stage disease. trended listing, transplant, then post-transplant follow-up visits (90 days, 180 annually).ResultsFourteen who were identified. At 10 out 14 noted have normal eGFR (GFR ≥ 90). By four these declined Stage 2 60 - 90, inclusive). All normalized by 1 year follow-up. The 4 < 90 all had further decline function time HT. Post-transplant, normalized, remained <90, required dialysis. progression is summarized figure below.ConclusionIn series, Cr appear be risk factors for progressive insufficiency undergoing predictive value other pre-transplant variables limited population size. calculations may help identify increased post benefit enhanced longitudinal surveillance. Unlike annually). Fourteen below.